For sake of comparison, ecological systems have a simple but challenging, genetically encoded mission in life to survive and reproduce to preserve its kind and culture in hostile environments that are full of hazards, adversaries, and predators, and most importantly, dynamic in its nature. Humans are not any different than other species, however, with an added aspiration of enhancing life quality, longevity, and happiness. Luckily, these risks faced by humans differ in occurrence rates (or odds), impacts, and in terms of our ability to recover from any impacts if they materialize. Figure 1 shows the scope and impacts of these risks on ordinal scales from the perspective of humans . The figure, inspired by an initial domain definition , does not show the important dimension of rates (or odds) for the various illustrative cases identified, and shows only the impact and scope with transgenerational and time dimensions and is intended to offer an illustrative basis for exhaustively scoping out risks for the purposes of this journal. The impact categories displayed are human-centric, i.e., anthropocentric, starting from nuisance to human health with the components of bodily injuries, mental health, and death, to property, and finally to the environment. The second scale of scope is also human-centric, and shows four categories from an individual to a group to a locality to worldwide, i.e., global. The examples provided in the figure cover many illustrative cases identified, from the mundane, tolerable risk of car damage due to a falling tree to the existential risk from an asteroid impacting Earth. Some of these risks are manageable, others are tolerable, some are inevitable, and a few could make us feel helpless.