This paper presents a novel procedure based on first-order reliability method (FORM) for structural reliability analysis in the presence of random parameters and interval uncertain parameters. In the proposed formulation, the hybrid problem is reduced to standard reliability problems, where the limit state functions are defined only in terms of the random variables. Monte Carlo simulation (MCS) for hybrid reliability analysis (HRA) is presented, and it is shown that it requires a tremendous computational effort; FORM for HRA is more efficient but still demanding. The computational cost is significantly reduced through a simplified procedure, which gives good approximations of the design points, by requiring only three classical FORMs and one interval analysis (IA), developed herein through an optimization procedure. FORM for HRA and its simplified formulation achieve a much improved efficiency than MCS by several orders of magnitude, and it can thus be applied to real-world engineering problems. Representative examples of stochastic dynamic analysis and performance-based engineering are presented.