An experimental and numerical study is performed to investigate heat transfer and pressure loss characteristics for impingement. Experimental heat transfer is measured by the thermochromic liquid crystal. The CFD model uses a steady state RANS approach and the shear stress transport (SST). The effect of Reynolds number (5000–25000), the distance between the holes and the distance from the hole to target on the impingement is investigated in the present study. Local Nusselt number as well as area and line average values are gotten experimentally and numerically. Besides, numerical simulations provide the detailed flow characteristics of the problem and complement experimental measurements. The result shows that the heat transfer increases with Reynolds number increasing. But the qualitative distribution of local heat transfer does not change with the increase of Reynolds number, when it is sensitive to P/D and Z/D. The performance of heat transfer is best when Z/D = 2. And the high heat transfer region of Z/D = 1 is closer to the exit than that of Z/D = 2 and Z/D = 3. The main reason is the effect of cross flow and the momentum of the jet reaching the wall. The performance of heat transfer is best when P/D = 5. And the high heat transfer region of P/D = 4 is closer to the exit than that of P/D = 5 and P/D = 6. The main reason is the effect of cross flow and interactions between jets.