Unsteady flow dynamics in a doubly constricted vessel is analyzed by using a time accurate Finite Volume solution of three dimensional incompressible Navier-Stokes equations. Computational experiments are carried out for various values of Reynolds number in order to assess the criticality of multiple mild constrictions in series and also to bring out the subtle 3D features like vortex formation. Studies reveal that pressure drop across a series of mild constrictions can get physiologically critical. Further this pressure drop is found to be sensitive to the spacing between the constrictions and also to the oscillatory nature of the inflow profile.

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