Many studies have focused on the effects of substrate rigidity on cell traction, migration, and differentiation [1–3]. Most cells are known to migrate toward the stiffer substrate, a phenomenon known as durotaxis. Recent reports have also demonstrated the ‘depth-sensing’ ability of cells on soft hydrogels where cell behaviors on thin gels are more similar to those on stiffer substrates [4–5]. Taking advantage of the high fidelity of microfabrication and soft lithography products, we created novel composite substrates composed of a top layer of collagen hydrogel and an underlying microstructure of silicon elastomer. We hypothesize that cells can sense the underlying microstructures and regulate cell translocation and morphology accordingly.
- Bioengineering Division
Effects of Composite Substrate Microstructure on Fibroblast Morphology and Migration
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Chang, W, Chahine, N, & Chao, PG. "Effects of Composite Substrate Microstructure on Fibroblast Morphology and Migration." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 959-960. ASME. https://doi.org/10.1115/SBC2011-53859
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