Mechanical loads affect growth and morphogenesis in the developing heart. Using a theoretical model, we studied stress-modulated growth in the embryonic chick ventricle during stages 21–29 (4–6 days of a 21-day incubation period). The model is a thick-walled, compressible, pseudoelastic cylinder, with finite volumetric growth included by letting the rate of change of the local zero-stress configuration depend linearly on the Cauchy stresses. After investigating the fundamental behavior of the model, we used it to study global and local growth in the primitive ventricle due to normal and abnormal cavity pressures. With end-diastolic pressure taken as the growth-modulating stimulus, correlating theoretical and available experimental results yielded the coefficients of the growth law, which was assumed to be independent of time and loading conditions. For both normal and elevated pressures, the predicted changes in radius and wall volume during development were similar to experimental measurements. In addition, the residual stress generated by differential growth agreed with experimental data. These results suggest that wall stress may be a biomechanical factor that regulates growth in the embryonic heart.
Skip Nav Destination
Article navigation
August 1995
Technical Papers
A Model for Stress-Induced Growth in the Developing Heart
I-En Lin,
I-En Lin
Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627
Search for other works by this author on:
L. A. Taber
L. A. Taber
Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627
Search for other works by this author on:
I-En Lin
Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627
L. A. Taber
Department of Mechanical Engineering, University of Rochester, Rochester, NY 14627
J Biomech Eng. Aug 1995, 117(3): 343-349 (7 pages)
Published Online: August 1, 1995
Article history
Received:
February 10, 1994
Revised:
July 26, 1994
Online:
October 30, 2007
Citation
Lin, I., and Taber, L. A. (August 1, 1995). "A Model for Stress-Induced Growth in the Developing Heart." ASME. J Biomech Eng. August 1995; 117(3): 343–349. https://doi.org/10.1115/1.2794190
Download citation file:
Get Email Alerts
Influence of Geometric Parameters on the Hemodynamic Characteristics of the Vertebral Artery
J Biomech Eng (March 2025)
Evaluating the Biomechanical Effects and Real-World Usability of a Novel Ankle Exo for Runners
J Biomech Eng (March 2025)
Related Articles
One Versus Two Implant-Retained Dentures: Comparing Biomechanics Under Oblique Mastication Forces
J Biomech Eng (May,2013)
Control of Circumferential Wall Stress and Luminal Shear Stress Within Intact Vascular Segments Perfused Ex Vivo
J Biomech Eng (October,2008)
Parameter Sensitivity Study of a Constrained Mixture Model of Arterial Growth and Remodeling
J Biomech Eng (October,2009)
Related Proceedings Papers
Related Chapters
Experimental Study of Planing Motion of a Cylinder Along the Nearly Axisymmetric Supercavity Surface
Proceedings of the 10th International Symposium on Cavitation (CAV2018)
Analysis of Cylindrical Shells
Stress in ASME Pressure Vessels, Boilers, and Nuclear Components
Stress Intensity Factors for Internally Pressurized Thick-Wall Cylinders
Stress Analysis and Growth of Cracks: Proceedings of the 1971 National Symposium on Fracture Mechanics: Part 1