A 3-dimensional formulation for a poroelastic and chemical electric (PEACE) model is presented and applied to an intervertebral disc slice in a 1-dimensional validation problem and a 2-dimensional plane stress problem. The model was used to investigate the influence of fixed charge density magnitude and distribution on this slice of disc material. Results indicated that the mechanical, chemical, and electrical behaviors were all strongly influenced by the amount as well as the distribution of fixed charges in the matrix. Without any other changes in material properties, alterations in the fixed charge density (proteoglycan content) from a healthy to a degenerated distribution will cause an increase in solid matrix stresses and can affect whether the tissue imbibes or exudes fluid under different loading conditions. Disc tissue with a degenerated fixed charge density distribution exhibited greater solid matrix stresses and decreased streaming potential, all of which have implications for disc nutrition, disc biomechanics, and tissue remodeling. It was also seen that application of an electrical potential across the disc can induce fluid transport.
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February 2003
Technical Papers
Influence of Fixed Charge Density Magnitude and Distribution on the Intervertebral Disc: Applications of a Poroelastic and Chemical Electric (PEACE) Model
James C. Iatridis, Assistant Professor,
James C. Iatridis, Assistant Professor
Dept. of Mechanical Engineering, University of Vermont, Burlington, VT 05405-0084
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Jeffrey P. Laible, Professor,
Jeffrey P. Laible, Professor
Dept. of Civil & Environmental Engineering, University of Vermont, Burlington, VT 05405-0084
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Martin H. Krag, Professor
Martin H. Krag, Professor
Dept. of Orthopaedics and Rehabilitation, and Vermont Back Research Center, University of Vermont, Burlington, VT 05405-0084
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James C. Iatridis, Assistant Professor
Dept. of Mechanical Engineering, University of Vermont, Burlington, VT 05405-0084
Jeffrey P. Laible, Professor
Dept. of Civil & Environmental Engineering, University of Vermont, Burlington, VT 05405-0084
Martin H. Krag, Professor
Dept. of Orthopaedics and Rehabilitation, and Vermont Back Research Center, University of Vermont, Burlington, VT 05405-0084
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received April 2001; revised manuscript received August 2002. Associate Editor: L. A. Taber .
J Biomech Eng. Feb 2003, 125(1): 12-24 (13 pages)
Published Online: February 14, 2003
Article history
Received:
April 1, 2001
Revised:
August 1, 2002
Online:
February 14, 2003
Citation
Iatridis, J. C., Laible, J. P., and Krag, M. H. (February 14, 2003). "Influence of Fixed Charge Density Magnitude and Distribution on the Intervertebral Disc: Applications of a Poroelastic and Chemical Electric (PEACE) Model ." ASME. J Biomech Eng. February 2003; 125(1): 12–24. https://doi.org/10.1115/1.1537190
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