A simple, cost effective, and noninvasive blood perfusion system is tested in animal models. The system uses a small sensor to measure the heat transfer response to a thermal event (convective cooling) imposed on the tissue surface. Heat flux data are compared with a mathematical model of the tissue to estimate both blood perfusion and thermal contact resistance between the tissue and the probe. The perfusion system was evaluated for repeatability and sensitivity using isolated rat liver and exposed rat kidney tests. Perfusion in the isolated liver tests was varied by controlling the flow of the perfusate into the liver, and the perfusion in the exposed kidney tests was varied by temporarily occluding blood flow through the renal artery and vein. The perfusion estimated by the convective perfusion probe was in good agreement with that of the metered flow of the perfusate into the liver model. The liver tests indicated that the probe can be used to detect small changes in perfusion (0.005 ml/ml/s). The probe qualitatively tracked the changes in the perfusion in the kidney model due to occlusion of the renal artery and vein.
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December 2008
Research Papers
Noninvasive Blood Perfusion Measurements of an Isolated Rat Liver and an Anesthetized Rat Kidney
Ashvinikumar V. Mudaliar,
Ashvinikumar V. Mudaliar
Modine Manufacturing Co.
, 1500 DeKoven Avenue, Racine, WI 53403-2552
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Brent E. Ellis,
Brent E. Ellis
Virginia Tech—Wake Forest University School of Biomedical Engineering and Sciences
, Department of Mechanical Engineering, Virginia Tech
, Blacksburg, VA 24061
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Patricia L. Ricketts,
Patricia L. Ricketts
Virginia Tech—Wake Forest University School of Biomedical Engineering and Sciences
, Department of Mechanical Engineering, Virginia Tech
, Blacksburg, VA 24061
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Otto I. Lanz,
Otto I. Lanz
Virginia Tech—Wake Forest University School of Biomedical Engineering and Sciences
, Department of Small Animal Clinical Sciences, Virginia Tech
, Blacksburg, VA 24061
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Charles Y. Lee,
Charles Y. Lee
Department of Mechanical Engineering and Engineering Science,
University of North Carolina at Charlotte
, 9201 University City Boulevard, Charlotte, NC 28223
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Thomas E. Diller,
Thomas E. Diller
Virginia Tech—Wake Forest University School of Biomedical Engineering and Sciences
, Department of Mechanical Engineering, Virginia Tech
, Blacksburg, VA 24061
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Elaine P. Scott
Elaine P. Scott
Virginia Tech—Wake Forest University School of Biomedical Engineering and Sciences
, Department of Mechanical Engineering, Virginia Tech
, Blacksburg, VA 24061; Department of Engineering, Seattle Pacific University
, 3307 3rd Avenue West, Seattle, WA 98119-1997
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Ashvinikumar V. Mudaliar
Modine Manufacturing Co.
, 1500 DeKoven Avenue, Racine, WI 53403-2552
Brent E. Ellis
Virginia Tech—Wake Forest University School of Biomedical Engineering and Sciences
, Department of Mechanical Engineering, Virginia Tech
, Blacksburg, VA 24061
Patricia L. Ricketts
Virginia Tech—Wake Forest University School of Biomedical Engineering and Sciences
, Department of Mechanical Engineering, Virginia Tech
, Blacksburg, VA 24061
Otto I. Lanz
Virginia Tech—Wake Forest University School of Biomedical Engineering and Sciences
, Department of Small Animal Clinical Sciences, Virginia Tech
, Blacksburg, VA 24061
Charles Y. Lee
Department of Mechanical Engineering and Engineering Science,
University of North Carolina at Charlotte
, 9201 University City Boulevard, Charlotte, NC 28223
Thomas E. Diller
Virginia Tech—Wake Forest University School of Biomedical Engineering and Sciences
, Department of Mechanical Engineering, Virginia Tech
, Blacksburg, VA 24061
Elaine P. Scott
Virginia Tech—Wake Forest University School of Biomedical Engineering and Sciences
, Department of Mechanical Engineering, Virginia Tech
, Blacksburg, VA 24061; Department of Engineering, Seattle Pacific University
, 3307 3rd Avenue West, Seattle, WA 98119-1997J Biomech Eng. Dec 2008, 130(6): 061013 (8 pages)
Published Online: October 15, 2008
Article history
Received:
July 25, 2007
Revised:
May 14, 2008
Published:
October 15, 2008
Citation
Mudaliar, A. V., Ellis, B. E., Ricketts, P. L., Lanz, O. I., Lee, C. Y., Diller, T. E., and Scott, E. P. (October 15, 2008). "Noninvasive Blood Perfusion Measurements of an Isolated Rat Liver and an Anesthetized Rat Kidney." ASME. J Biomech Eng. December 2008; 130(6): 061013. https://doi.org/10.1115/1.2978989
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