Stress relaxation tests using a custom designed microindentation device were performed on ten anatomic regions of fresh porcine brain (postmortem time <3 h). Using linear viscoelastic theory, a Prony series representation was used to describe the shear relaxation modulus for each anatomic region tested. Prony series parameters fit to load data from indentations performed to ∼10% strain differed significantly by anatomic region. The gray and white matter of the cerebellum along with corpus callosum and brainstem were the softest regions measured. The cortex and hippocampal CA1/CA3 were found to be the stiffest. To examine the large strain behavior of the tissue, multistep indentations were performed in the corona radiata to strains of 10%, 20%, and 30%. Reduced relaxation functions were not significantly different for each step, suggesting that quasi-linear viscoelastic theory may be appropriate for representing the nonlinear behavior of this anatomic region of porcine brain tissue. These data, for the first time, describe the dynamic and short time scale behavior of multiple anatomic regions of the porcine brain which will be useful for understanding porcine brain injury biomechanics at a finer spatial resolution than previously possible.
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July 2011
Research Papers
Dynamic, Regional Mechanical Properties of the Porcine Brain: Indentation in the Coronal Plane
Benjamin S. Elkin,
Benjamin S. Elkin
Department of Biomedical Engineering,
Columbia University
, New York 10027, NY
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Ashok Ilankova,
Ashok Ilankova
Department of Biomedical Engineering,
Columbia University
, New York 10027, NY
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Barclay Morrison, III
Barclay Morrison, III
Department of Biomedical Engineering,
Columbia University
, New York 10027, NY
Search for other works by this author on:
Benjamin S. Elkin
Department of Biomedical Engineering,
Columbia University
, New York 10027, NY
Ashok Ilankova
Department of Biomedical Engineering,
Columbia University
, New York 10027, NY
Barclay Morrison, III
Department of Biomedical Engineering,
Columbia University
, New York 10027, NYJ Biomech Eng. Jul 2011, 133(7): 071009 (7 pages)
Published Online: July 29, 2011
Article history
Received:
February 28, 2011
Revised:
June 12, 2011
Posted:
June 30, 2011
Published:
July 29, 2011
Online:
July 29, 2011
Citation
Elkin, B. S., Ilankova, A., and Morrison, B., III (July 29, 2011). "Dynamic, Regional Mechanical Properties of the Porcine Brain: Indentation in the Coronal Plane." ASME. J Biomech Eng. July 2011; 133(7): 071009. https://doi.org/10.1115/1.4004494
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