...Babak N. Safa; Nina Sara Fraticelli Guzmán; Guorong Li; W. Daniel Stamer; Andrew J. Feola; C. Ross Ethier Murine models are commonly used to study glaucoma, the leading cause of irreversible blindness. Glaucoma is associated with elevated intra-ocular pressure (IOP), which is regulated...

... of glaucoma and glaucoma optic nerve damage, and investigate the relationship between the structure and pressure-induced strain response of the LC in glaucoma eyes. Previously, the posterior scleral cups of 10 normal eyes and 16 diagnosed glaucoma eyes were subjected to inflation testing with second harmonic...

.... Editor: Jonathan Vande Geest. 20 01 2014 15 12 2014 sclera glaucoma collagen fiber finite element model digital image correlation inverse finite element analysis wide angle X-ray scattering The sclera, which constitutes more than 80% of the eye-wall, is the white outer...

... in the onset or further development of glaucoma, including in patients with relatively normal intraocular pressures (IOPs). Characterizing posterior scleral deformations over physiological pressures may provide a better understanding of how changes in IOP lead to changes in the mechanical environment...

...Joseph T. Keyes; Dongmei Yan; Jacob H. Rader; Urs Utzinger; Jonathan P. Vande Geest The biomechanical model of glaucoma considers intraocular pressure-related stress and resultant strain on load bearing connective tissues of the optic nerve and surrounding peripapillary sclera as one major...

... role in and are altered by the development of glaucoma—an ocular disease manifested by structural damage to the optic nerve head. An anisotropic hyperelastic constitutive model is presented to simulate the mechanical behavior of the posterior sclera under acute elevations of intraocular pressure...

...Michaël J. A. Girard; J. Crawford Downs; Michael Bottlang; Claude F. Burgoyne; J.-K. Francis Suh The posterior sclera likely plays an important role in the development of glaucoma, and accurate characterization of its mechanical properties is needed to understand its impact on the more delicate...

...Tim Newson; Ahmed El-Sheikh Comprehensive understanding of the biomechanical performance of the lamina cribrosa (LC) and the optic nerve head is central to understanding the role of elevated intraocular pressures (IOP) in chronic open angle glaucoma. In this paper, six closed-from mathematical...