...Zachary Appel; Arthur J. Michalek Intradiscal injection is required to deliver therapeutic agents to the intervertebral disc (IVD) nucleus pulposus (NP). However, injectate leakage following needle retraction may result in decreased treatment efficacy and adverse side effects. While enzymatic...

.... , and Masouros , S. D. , 2017 , “ Biomechanics of the Human Intervertebral Disc: A Review of Testing Techniques and Results ,” J. Mech. Behav. Biomed. Mater. , 69 , pp. 420 – 434 . 10.1016/j.jmbbm.2017.01.037 [5] Costi , J. J. , Ledet , E. H. , and O'Connell , G. D. , 2021...

...Sabrina I. Sinopoli; Diane E. Gregory The annulus fibrosus is the ring-like exterior of the intervertebral disc, which is composed of concentrically organized layers of collagen fiber bundles. The mechanical properties of the annulus have been studied extensively; however, tests are typically...

.... , and Marcolongo , M. , 2008 , “ The Role of the Nucleus Pulposus in Neutral Zone Human Lumbar Intervertebral Disc Mechanics ,” J. Biomech. , 41 ( 10 ), pp. 2104 – 2111 . 10.1016/j.jbiomech.2008.04.037 [3] Huang , J. , Yan , H. , Jian , F. , Wang , X. , and Li , H...

...Ruspi Maria Luisa; Cristofolini Luca Contrasting results are reported when the spine is tested at different strain rates. Tissue specimens from the ligaments or the intervertebral discs (IVD, including annulus fibrosus and nucleus pulposus) exhibit higher stiffness and lower dissipation at high...

...Mirit Sharabi; Aviad Levi-Sasson; Roza Wolfson; Kelly R. Wade; Fabio Galbusera; Dafna Benayahu; Hans-Joachim Wilke; Rami Haj-Ali The annulus fibrosus (AF) of the intervertebral disc (IVD) consists of a set of concentric layers composed of a primary circumferential collagen fibers arranged...

...Jonathon H. Yoder; John M. Peloquin; Gang Song; Nick J. Tustison; Sung M. Moon; Alexander C. Wright; Edward J. Vresilovic; James C. Gee; Dawn M. Elliott References [1] Buckwalter , J. A. , and Mow , V. C. , 2000 , “ Intervertebral Disc Structure, Composition, Mechanical Function...

... to 20% of the general population. Many of these injuries are specifically related to the intervertebral disc, including discogenic pain and accelerated disc degeneration. Numerous studies have characterized the mechanical behavior of the disc under normal physiological loads, while several have also...

... manuscript posted April 22, 2013; published online May 9, 2013. Assoc. Editor: Yener N. Yeni. 05 07 2012 07 03 2013 22 04 2013 Repeated flexion and extension of an intervertebral disc has been shown to affect the angular stiffness of spinal motion segments and is a barometer...

...Maximilien Recuerda; Simon-Pierre Coté; Isabelle Villemure; Delphine Périé The lack of standardization in experimental protocols for unconfined compression tests of intervertebral discs (IVD) tissues is a major issue in the quantification of their mechanical properties. Our hypothesis...

...Edward J. Vresilovic; Wade Johannessen; Dawn M. Elliott Mechanical function of the intervertebral disc is maintained through the interaction between the hydrated nucleus pulposus, the surrounding annulus fibrosus, and the superior and inferior endplates. In disc degeneration the normal transfer...

... intervertebral discs (IVDs) were tested in compression for intact, denucleated, and implanted condition. Implantation of nucleus implants with different material and geometric parameters into a denucleated IVD significantly altered the IVD compressive stiffness. Variations in the nucleus implant parameters...

...D. C. Ayotte; K. Ito; S. M. Perren; S. Tepic We hypothesize that a direction-dependent flow resistance exists in the intervertebral disc due to constriction flow in the cartilage endplates. A comparison of the hydrostatic pressure in the nucleus of the healthy intervertebral disc during daily...