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Journal Articles

Simulating the Growth of TATA-Box Binding Protein-Associated Factor 15 Inclusions in Neuron Soma

Andrey V. Kuznetsov
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2024, 146(12): 121010.
Paper No: BIO-24-1185
https://doi.org/10.1115/1.4066386
Published Online: October 3, 2024
... of free TAF15 aggregates into TAF15 inclusions. e-mail:  avkuznet@ncsu.edu 14 07 2024 25 08 2024 03 10 2024 frontotemporal lobar degeneration TATA-binding protein-associated factor 15 prion-like domain protein aggregation neuron Finke−Watzky model...
View Article titled, Simulating the Growth of TATA-Box Binding Protein-Associated Factor 15 Inclusions in <span class="search-highlight">Neuron</span> Soma
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Topics: Proteins, Nucleation (Physics)
Includes: Supplementary data
Journal Articles

Numerical and Analytical Simulation of the Growth of Amyloid-β Plaques

Andrey V. Kuznetsov
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2024, 146(6): 061004.
Paper No: BIO-23-1333
https://doi.org/10.1115/1.4064969
Published Online: March 25, 2024
... 2024 25 03 2024 neuron Alzheimer's disease Finke−Watzky model mathematical modeling polymerization cube root hypothesis Division of Chemical, Bioengineering, Environmental, and Transport Systems 10.13039/100000146 CBET-2042834 Alzheimer's disease (AD...
View Article titled, Numerical and Analytical Simulation of the Growth of Amyloid-β Plaques
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Topics: Half-life, Nucleation (Physics), Machinery, Simulation
Includes: Supplementary data
Journal Articles

Dynein Dysfunction Prevents Maintenance of High Concentrations of Slow Axonal Transport Cargos at the Axon Terminal: A Computational Study

Ivan A. Kuznetsov, Andrey V. Kuznetsov
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2023, 145(7): 071001.
Paper No: BIO-22-1199
https://doi.org/10.1115/1.4056915
Published Online: March 28, 2023
... with peripheral motor and sensory neurons, such as type 2O Charcot-Marie-Tooth disease. We use two different models to simulate bidirectional transport in an axon: an anterograde-retrograde model, which neglects passive transport by diffusion in the cytosol, and a full slow transport model, which includes passive...
View Article titled, Dynein Dysfunction Prevents Maintenance of High Concentrations of Slow Axonal Transport Cargos at the Axon Terminal: A Computational Study
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Topics: Diffusion (Physics), Maintenance, Motors, Proteins, Engines, Boundary-value problems, Modeling
Includes: Supplementary data
Journal Articles

A Numerical Study of Sensitivity Coefficients for a Model of Amyloid Precursor Protein and Tubulin-Associated Unit Protein Transport and Agglomeration in Neurons at the Onset of Alzheimer's Disease

I. A. Kuznetsov, A. V. Kuznetsov
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2019, 141(3): 031006.
Paper No: BIO-18-1293
https://doi.org/10.1115/1.4041905
Published Online: January 18, 2019
... Disease Research ,” Neuron , 52 ( 1 ), pp. 3 – 13 . 10.1016/j.neuron.2006.09.016 [2] Maqbool , M. , Mobashir , M. , and Hoda , N. , 2016 , “ Pivotal Role of Glycogen Synthase Kinase-3: A Therapeutic Target for Alzheimer's Disease ,” Eur. J. Med. Chem. , 107 , pp. 63 – 81...
View Article titled, A Numerical Study of Sensitivity Coefficients for a Model of Amyloid Precursor Protein and Tubulin-Associated Unit Protein Transport and Agglomeration in <span class="search-highlight">Neurons</span> at the Onset of Alzheimer&#x27;s Disease
Open the PDF for A Numerical Study of Sensitivity Coefficients for a Model of Amyloid Precursor Protein and Tubulin-Associated Unit Protein Transport and Agglomeration in <span class="search-highlight">Neurons</span> at the Onset of Alzheimer's Disease in another window
Topics: Diseases, Proteins, Sensitivity analysis, Agglomeration (Materials), Modeling
Includes: Supplementary data