Fuel availability, global warming, and energy security are the three main driving forces, which determine suitability and long-term implementation potential of a renewable fuel for internal combustion engines for a variety of applications. Comprehensive engine experiments were conducted in a single-cylinder gasoline direct injection (GDI) engine prototype having a compression ratio of 10.5, for gaining insights into application of mixtures of gasoline and primary alcohols. Performance, emissions, combustion, and particulate characteristics were determined at different engine speeds (1500, 2000, 2500, 3000 rpm), different fuel injection pressures (FIP: 40, 80, 120, 160 bars) and different test fuel blends namely 15% (v/v) butanol, ethanol, and methanol blended with gasoline, respectively (Bu15, E15, and M15) and baseline gasoline at a fixed (optimum) spark timing of 24 deg before top dead center (bTDC). For a majority of operating conditions, gasohols exhibited superior characteristics except minor engine performance penalty. Gasohols therefore emerged as serious candidate as a transitional renewable fuel for utilization in the existing GDI engines, without requirement of any major hardware changes.