The increasing environmental limits and carbon emissions taxes are substantial to develop the efficient systems for offering an effective energy utilization. This study proposed a new biomass-based gasification-assisted configuration for the renewable hydrogen production system offering efficient energy utilization. A multi-effect desalination system is employed for water desalination which is converted to steam and fed to the entrained flow gasifier. The integrated heat recovery steam generator gains the additional heat from the syngas to generate steam using fresh water from the desalination unit. The produced hydrogen is supplied to the multistage compression unit that stores hydrogen at high pressure. Industrial aspen plus software V9 version is employed for the simulation under the RK-SOAVE property method. The production of hydrogen before the water gas shift reactor is 129.5 mol/s and after the water gas shift reactor is found to be 171 mol/s. The thermodynamic performance of the biomass energy-assisted system is determined through overall energetic and exergetic efficiencies that are revealed to be 40.86% and 38.63%. Numerous sensitivity studies are performed to explore the performance of the designed system and presented and discussed.