An investigation is made to study the Blasius flow of a nanofluid in the presence of homogeneous–heterogeneous chemical reactions. Here, the diffusion coefficients of the reactant and autocatalyst are considered to be in comparable sizes. The Buongiorno's mathematical model is applied in describing the behavior of nanofluids. Multiple solutions of the steady-state system of nonlinear ordinary differential equations are obtained. Results show that nanofluids significantly participate in the transport mechanism of the homogeneous–heterogeneous reactions, which play different roles in the procedures of homogeneous and heterogeneous reactions.

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