Parameter estimation techniques have been utilized in the development of a methodology to noninvasively measure blood perfusion using a new thermal surface probe. The core of this probe is comprised of a small, lightweight heat flux sensor that is placed in contact with tissue and provides time-resolved signals of heat flux and surface temperature while the probe is cooled by air jets. Parameter estimation techniques were developed that incorporate heat flux and temperature data with calculated data from a biothermal model of the tissue and probe. The technique simultaneously estimates blood perfusion and thermal contact resistance between the probe and tissue. Validation of this concept was carried out by experimentation with controlled flow through nonbiological porous media. Warm water was circulated through a fine pore sponge to provide a phantom model for blood perfusion through biological tissue. The parameter estimation technique was applied to measurements taken over a range of flow rates. Heat flux and temperature measurements and the resulting perfusion estimates correlated well with the experimentally imposed perfusion rate. This research helps establish the validity of using this method to develop a practical, noninvasive probe to clinically measure blood perfusion.
Skip Nav Destination
Article navigation
March 2008
Research Papers
Testing of a Noninvasive Probe for Measurement of Blood Perfusion
Paul S. Robinson,
Paul S. Robinson
Department of Mechanical Engineering
, Virginia Tech, Blacksburg, VA 24060
Search for other works by this author on:
Elaine P. Scott,
Elaine P. Scott
Department of Engineering,
Seattle Pacific University, Seattle, WA 98119
Search for other works by this author on:
Thomas E. Diller
Thomas E. Diller
Department of Mechanical Engineering
, Virginia Tech, Blacksburg, VA 24060
Search for other works by this author on:
Paul S. Robinson
Department of Mechanical Engineering
, Virginia Tech, Blacksburg, VA 24060
Elaine P. Scott
Department of Engineering,
Seattle Pacific University, Seattle, WA 98119
Thomas E. Diller
Department of Mechanical Engineering
, Virginia Tech, Blacksburg, VA 24060J. Med. Devices. Mar 2008, 2(1): 011001 (5 pages)
Published Online: March 7, 2008
Article history
Received:
October 20, 2006
Revised:
November 14, 2007
Published:
March 7, 2008
Citation
Robinson, P. S., Scott, E. P., and Diller, T. E. (March 7, 2008). "Testing of a Noninvasive Probe for Measurement of Blood Perfusion." ASME. J. Med. Devices. March 2008; 2(1): 011001. https://doi.org/10.1115/1.2884190
Download citation file:
Get Email Alerts
Cited By
Related Articles
A Phantom Tissue System for the Calibration of Perfusion Measurements
J Biomech Eng (October,2008)
Modeling and Estimating Simulated Burn Depth Using the Perfusion and Thermal Resistance Probe
J. Med. Devices (September,2013)
New Mathematical Model to Estimate Tissue Blood Perfusion, Thermal Contact Resistance and Core Temperature
J Biomech Eng (August,2012)
Noninvasive Blood Perfusion Measurements of an Isolated Rat Liver and an Anesthetized Rat Kidney
J Biomech Eng (December,2008)
Related Proceedings Papers
Related Chapters
Experimental results
Ultrasonic Methods for Measurement of Small Motion and Deformation of Biological Tissues for Assessment of Viscoelasticity
Conjugate Priors with Zero Occurrences: Analyst Beware! (PSAM-0435)
Proceedings of the Eighth International Conference on Probabilistic Safety Assessment & Management (PSAM)
Parameter Estimation of the Duffing Oscillator Using Poincaré Map and an Elitist Genetic Algorithm
Intelligent Engineering Systems through Artificial Neural Networks, Volume 20