Bioimpedance spectroscopy (BIS) has shown significant potential in many areas of medicine to provide new physiologic markers. Several acute and chronic diseases are accompanied by changes in intra- and extracellular fluid within various areas of the human body. The estimation of fluid in various body compartments is therefore a simple and convenient method to monitor certain disease states. In this work, the design and evaluation of a BIS instrument are presented and three key areas of the development process investigated facilitating the BIS measurement of tissue hydration state. First, the benefit of incorporating DC-stabilizing circuitry to the standard modified Howland current pump (MHCP) is investigated to minimize the effect of DC offsets limiting the dynamic range of the system. Second, the influence of the distance between the bioimpedance probe and a high impedance material is investigated using finite element analysis (FEA). Third, an analytic compensation technique is presented to minimize the influence of parasitic capacitance. Finally, the overall experimental setup is evaluated through ex vivo BIS measurements of porcine spleen tissue and compared to published results. The DC-stabilizing circuit demonstrated its ability to maintain DC offsets at less than 650 μV through 100 kHz while maintaining an output impedance of 1 MΩ from 100 Hz to 100 kHz. The proximity of a bioimpedance probe to a high impedance material such as acrylic was shown to increase measured impedance readings by a factor of 4x as the ratio of the distance between the sensing electrodes to the distance between the bioimpedance probe and acrylic reached 1:3. The average parasitic capacitance for the circuit presented was found to be 712 ± 128 pF, and the analytic compensation method was shown to be able to minimize this effect on the BIS measurements. Measurements of porcine spleen tissue showed close correlation with experimental results reported in published articles. This research presents the successful design and evaluation of a BIS instrument. Specifically, robust measurements were obtained by implementing a DC-stabilized current source, investigating probe-material proximity issues and compensating for parasitic capacitance. These strategies were shown to provide tissue measurements comparable with published literature.
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June 2015
Research-Article
Design of Bioimpedance Spectroscopy Instrument With Compensation Techniques for Soft Tissue Characterization
Grant H. Kruger,
Grant H. Kruger
Mechanical Engineering,
1031 H.H. Dow Building,
2350 Hayward Street,
e-mail: ghkruger@umich.edu
University of Michigan
,1031 H.H. Dow Building,
2350 Hayward Street,
Ann Arbor, MI 48109
e-mail: ghkruger@umich.edu
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Albert J. Shih
Albert J. Shih
Mechanical Engineering,
3001E EECS,
1301 Beal,
e-mail: shiha@umich.edu
University of Michigan
,3001E EECS,
1301 Beal,
Ann Arbor, MI 48109
e-mail: shiha@umich.edu
Search for other works by this author on:
Robert E. Dodde
Grant H. Kruger
Mechanical Engineering,
1031 H.H. Dow Building,
2350 Hayward Street,
e-mail: ghkruger@umich.edu
University of Michigan
,1031 H.H. Dow Building,
2350 Hayward Street,
Ann Arbor, MI 48109
e-mail: ghkruger@umich.edu
Albert J. Shih
Mechanical Engineering,
3001E EECS,
1301 Beal,
e-mail: shiha@umich.edu
University of Michigan
,3001E EECS,
1301 Beal,
Ann Arbor, MI 48109
e-mail: shiha@umich.edu
1Corresponding author.
Manuscript received February 22, 2014; final manuscript received January 22, 2015; published online April 24, 2015. Assoc. Editor: Carl Nelson.
J. Med. Devices. Jun 2015, 9(2): 021001 (8 pages)
Published Online: June 1, 2015
Article history
Received:
February 22, 2014
Revision Received:
January 22, 2015
Online:
April 24, 2015
Citation
Dodde, R. E., Kruger, G. H., and Shih, A. J. (June 1, 2015). "Design of Bioimpedance Spectroscopy Instrument With Compensation Techniques for Soft Tissue Characterization." ASME. J. Med. Devices. June 2015; 9(2): 021001. https://doi.org/10.1115/1.4029706
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