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Grace D. O'Connell
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Journal Articles

Quantification of Internal Disc Strain Under Dynamic Loading Via High-Frequency Ultrasound

Elnaz Ghajar-Rahimi, Diya D. Sakhrani, Radhika S. Kulkarni, Shiyin Lim, Blythe Dumerer, Annie Labine, Michael E. Abbott, Grace D. O'Connell, Craig J. Goergen
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. March 2025, 147(3): 034501.
Paper No: BIO-24-1142
https://doi.org/10.1115/1.4067330
Published Online: January 17, 2025
View Article titled, Quantification of Internal Disc Strain Under Dynamic Loading Via High-Frequency Ultrasound
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Topics: Compression, Deformation, Disks, Dynamic testing (Materials), Ultrasound, Texture (Materials), Image processing
Journal Articles

Torque- and Muscle-Driven Flexion Induce Disparate Risks of In Vitro Herniation: A Multiscale and Multiphasic Structure-Based Finite Element Study

Minhao Zhou, Reece D. Huff, Yousuf Abubakr, Grace D. O'Connell
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2022, 144(6): 061005.
Paper No: BIO-21-1363
https://doi.org/10.1115/1.4053402
Published Online: February 21, 2022
View Article titled, Torque- and Muscle-Driven Flexion Induce Disparate Risks of In Vitro Herniation: A Multiscale and Multiphasic Structure-Based Finite Element Study
Open the PDF for Torque- and Muscle-Driven Flexion Induce Disparate Risks of In Vitro Herniation: A Multiscale and Multiphasic Structure-Based Finite Element Study in another window
Topics: Disks, Failure, Muscle, Risk, Torque, Stress, Biological tissues
Includes: Supplementary data
Journal Articles

Intervertebral Disc Mechanics With Nucleotomy: Differences Between Simple and Dual Loading

Bo Yang, Eric Klineberg, Grace D. O'Connell
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. August 2021, 143(8): 081002.
Paper No: BIO-20-1032
https://doi.org/10.1115/1.4050538
Published Online: April 21, 2021
View Article titled, Intervertebral Disc Mechanics With Nucleotomy: Differences Between Simple and Dual Loading
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Topics: Compression, Disks, Fibers, Stiffness, Stress, Torsion, Intervertebral discs, Joint mechanics
Journal Articles

Relative Nucleus Pulposus Area and Position Alter Disk Joint Mechanics

Bo Yang, Yintong Lu, Colin Um, Grace D. O'Connell
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. May 2019, 141(5): 051004.
Paper No: BIO-18-1287
https://doi.org/10.1115/1.4043029
Published Online: March 25, 2019
View Article titled, Relative Nucleus Pulposus Area and Position Alter Disk Joint Mechanics
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Topics: Compression, Disks, Rotation, Stiffness, Pressure, Stress, Geometry, Joint mechanics
Proceedings Papers

Customization of a 3D Printed Prosthetic Finger Using Parametric Modeling

Daniel Lim, Thomás Georgiou, Aashish Bhardwaj, Grace D. O’Connell, Alice M. Agogino
Proc. ASME. IDETC-CIE2018, Volume 2A: 44th Design Automation Conference, V02AT03A034, August 26–29, 2018
Publisher: American Society of Mechanical Engineers
Paper No: DETC2018-85645
https://doi.org/10.1115/DETC2018-85645
View Paper titled, Customization of a 3D Printed Prosthetic Finger Using Parametric Modeling
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Topics: Additive manufacturing, Artificial limbs, Modeling, Prostheses, Design, Design engineering, Linkages, Medical devices, Weight (Mass)
Journal Articles

Effect of Hydration on Healthy Intervertebral Disk Mechanical Stiffness

Semih E. Bezci, Aditya Nandy, Grace D. O'Connell
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. October 2015, 137(10): 101007.
Paper No: BIO-14-1647
https://doi.org/10.1115/1.4031416
Published Online: September 3, 2015
View Article titled, Effect of Hydration on Healthy Intervertebral Disk Mechanical Stiffness
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Topics: Biological tissues, Disks, Stiffness, Intervertebral discs, Stress, Creep, Water, Compression
Proceedings Papers

An Anisotropic Hyperelastic Model Applied to Nondegenerate and Degenerate Annulus Fibrosus

Grace D. O’Connell, Heather L. Guerin, Dawn M. Elliott
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 1107-1108, June 25–29, 2008
Publisher: American Society of Mechanical Engineers
Paper No: SBC2008-192890
https://doi.org/10.1115/SBC2008-192890
View Paper titled, An Anisotropic Hyperelastic Model Applied to Nondegenerate and Degenerate Annulus Fibrosus
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Topics: Anisotropy, Annulus, Fibers, Disks, Biological tissues, Tensors, Deformation, Finite element model, Intervertebral discs, Mechanical behavior
Proceedings Papers

Multi-Lamellar and Multi-Axial Maturation of Cell-Seeded Fiber-Reinforced Tissue Engineered Constructs

Brendon M. Baker, Grace D. O’Connell, Sounok Sen, Ashwin S. Nathan, Dawn M. Elliott, Robert L. Mauck
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 1013-1014, June 20–24, 2007
Publisher: American Society of Mechanical Engineers
Paper No: SBC2007-176434
https://doi.org/10.1115/SBC2007-176434
View Paper titled, Multi-Lamellar and Multi-Axial Maturation of Cell-Seeded Fiber-Reinforced Tissue Engineered Constructs
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Topics: Biological tissues, Fibers, Knee, Annulus, Anisotropy, Bearings, Intervertebral discs, Laminates, Mechanical properties, Nanoscale phenomena
Proceedings Papers

Biaxial Mechanics of Musculoskeletal Tissue and Fiber-Reinforced Scaffolds

Grace D. O’Connell, Sounok Sen, Brendon M. Baker, Robert L. Mauck, Dawn M. Elliott
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 935-936, June 20–24, 2007
Publisher: American Society of Mechanical Engineers
Paper No: SBC2007-176540
https://doi.org/10.1115/SBC2007-176540
View Paper titled, Biaxial Mechanics of Musculoskeletal Tissue and Fiber-Reinforced Scaffolds
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Topics: Biological tissues, Fibers, Musculoskeletal system, Boundary-value problems, Cardiovascular system, Geometry, Mechanical testing, Stress, Tensile testing
Proceedings Papers

Differences in Engineered Cartilage From Human Chondrocytes and Mesenchymal Stem Cells in Pellet and Construct Culture

Grace D. O’Connell, Victoria H. Cui, Glyn Palmer, Clark T. Hung
Proc. ASME. SBC2013, Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments, V01AT17A017, June 26–29, 2013
Publisher: American Society of Mechanical Engineers
Paper No: SBC2013-14435
https://doi.org/10.1115/SBC2013-14435
View Paper titled, Differences in Engineered Cartilage From Human Chondrocytes and Mesenchymal Stem Cells in Pellet and Construct Culture
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Topics: Cartilage, Chondrocytes, Stem cells, Osteoarthritis, Bearings, Biological tissues, Hydrogels, Mechanical properties, Stress, Tissue engineering
Proceedings Papers

Prolonged Treatment of Ultra-Low Dose Chondroitinase ABC Improves Matrix Production in Engineered Cartilage

Grace D. O’Connell, Victoria Cui, Robert J. Nims, Adam B. Nover, Gerard A. Ateshian, Clark T. Hung
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT39A002, June 26–29, 2013
Publisher: American Society of Mechanical Engineers
Paper No: SBC2013-14191
https://doi.org/10.1115/SBC2013-14191
View Paper titled, Prolonged Treatment of Ultra-Low Dose Chondroitinase ABC Improves Matrix Production in Engineered Cartilage
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Topics: Cartilage, Stress, Bearings, Biological tissues, Equilibrium (Physics), Soft tissues
Proceedings Papers

Chondroitinase-ABC Digestion and Dynamic Loading Increase Tension-Compression Nonlinearity in Tissue-Engineered Cartilage

Terri-Ann N. Kelly, Brendan L. Roach, Charles R. Mackenzie-Smith, Adam B. Nover, Eben G. Estell, Grace D. O’Connell, Gerard A. Ateshian, Clark T. Hung
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT39A008, June 26–29, 2013
Publisher: American Society of Mechanical Engineers
Paper No: SBC2013-14621
https://doi.org/10.1115/SBC2013-14621
View Paper titled, Chondroitinase-ABC Digestion and Dynamic Loading Increase Tension-Compression Nonlinearity in Tissue-Engineered Cartilage
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Topics: Biological tissues, Cartilage, Compression, Dynamic testing (Materials), Tension, Mechanical properties, Strength (Materials), Tensile strength, Young's modulus
Proceedings Papers

Lipid Mictrotubes as a Nutrient Reservoir or Enzyme Delivery Vehicle in Engineered Cartilage

Grace D. O’Connell, Clare Gollnick, Gerard A. Ateshian, Ravi V. Bellamkonda, Clark T. Hung
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 943-944, June 20–23, 2012
Publisher: American Society of Mechanical Engineers
Paper No: SBC2012-80472
https://doi.org/10.1115/SBC2012-80472
View Paper titled, Lipid Mictrotubes as a Nutrient Reservoir or Enzyme Delivery Vehicle in Engineered Cartilage
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Topics: Cartilage, Enzymes, Reservoirs, Vehicles, Biological tissues, Diffusion (Physics), Hydrogels, Agar, Chords (Trusses), Inspection
Proceedings Papers

Characterization of Depth-Dependent Mechanical Properties in Bio-Titanium Hybrid Osteochondral Tissue Engineered Constructs

Adam B. Nover, Katherine C. Wood, Grace D. O’Connell, Aaron P. Essner, Robert W. Klein, Anthony P. Napolitano, Eric G. Lima, Gerard A. Ateshian, Clark T. Hung
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 1143-1144, June 20–23, 2012
Publisher: American Society of Mechanical Engineers
Paper No: SBC2012-80600
https://doi.org/10.1115/SBC2012-80600
View Paper titled, Characterization of Depth-Dependent Mechanical Properties in Bio-Titanium Hybrid Osteochondral Tissue Engineered Constructs
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Topics: Biological tissues, Mechanical properties, Titanium, Bone, Cartilage, Chondrocytes, Hydrogels, Metals, Tantalum
Proceedings Papers

Experimental and Theoretical Evaluation of Failure Properties for Immature Tissue Engineered Cartilage

Grace D. O’Connell, Clark T. Hung, Gerard A. Ateshian
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 1193-1194, June 22–25, 2011
Publisher: American Society of Mechanical Engineers
Paper No: SBC2011-53385
https://doi.org/10.1115/SBC2011-53385
View Paper titled, Experimental and Theoretical Evaluation of Failure Properties for Immature Tissue Engineered Cartilage
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Topics: Biological tissues, Cartilage, Failure, Stress, Knee, Maintenance, Agar, Bearings, Bioreactors, Dimensions
Proceedings Papers

Beneficial Effects of Chondroitinase ABC Release From Lipid Microtubes Encapsulated in Chondrocyte-Seeded Hydrogel Constructs

Grace D. O’Connell, Clare Gollnick, Gerard A. Ateshian, Ravi V. Bellamkonda, Clark T. Hung
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 893-894, June 22–25, 2011
Publisher: American Society of Mechanical Engineers
Paper No: SBC2011-53832
https://doi.org/10.1115/SBC2011-53832
View Paper titled, Beneficial Effects of Chondroitinase ABC Release From Lipid Microtubes Encapsulated in Chondrocyte-Seeded Hydrogel Constructs
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Topics: Chondrocytes, Hydrogels, Cartilage, Enzymes, Biological tissues, Agar, Diffusion (Physics), Mechanical properties
Journal Articles

Theoretical and Uniaxial Experimental Evaluation of Human Annulus Fibrosus Degeneration

Grace D. O’Connell, Heather L. Guerin, Dawn M. Elliott
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. November 2009, 131(11): 111007.
https://doi.org/10.1115/1.3212104
Published Online: October 21, 2009
View Article titled, Theoretical and Uniaxial Experimental Evaluation of Human Annulus Fibrosus Degeneration
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Topics: Anisotropy, Annulus, Biological tissues, Fibers, Shear (Mechanics), Stress, Mechanical properties, Mechanical testing, Modeling